SUMO-mediated regulation of NLRP3 modulates inflammasome activity

The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. How the NLRP3 inflammasome is negatively regulated is poorly understood. Here we show that NLRP3 inflammasome act...

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Detalles Bibliográficos
Autores principales: Barry, Rachael, John, Sidonie Wicky, Liccardi, Gianmaria, Tenev, Tencho, Jaco, Isabel, Chen, Chih-Hong, Choi, Justin, Kasperkiewicz, Paulina, Fernandes-Alnemri, Teresa, Alnemri, Emad, Drag, Marcin, Chen, Yuan, Meier, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070540/
https://www.ncbi.nlm.nih.gov/pubmed/30069026
http://dx.doi.org/10.1038/s41467-018-05321-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070540/
https://www.ncbi.nlm.nih.gov/pubmed/30069026
http://dx.doi.org/10.1038/s41467-018-05321-2

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