A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

A poorly exploited paradigm in the antimicrobial therapy field is to target virulence traits for drug development. In contrast to target-focused approaches, antivirulence phenotypic screens enable identification of bioactive molecules that induce a desirable biological readout without making a prior...

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Detalles Bibliográficos
Autores principales: Garcia, Carlos, Burgain, Anaïs, Chaillot, Julien, Pic, Émilie, Khemiri, Inès, Sellam, Adnane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070544/
https://www.ncbi.nlm.nih.gov/pubmed/30068935
http://dx.doi.org/10.1038/s41598-018-29973-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070544/
https://www.ncbi.nlm.nih.gov/pubmed/30068935
http://dx.doi.org/10.1038/s41598-018-29973-8

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