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Genome-Scale Metabolic Model of Actinosynnema pretiosum ATCC 31280 and Its Application for Ansamitocin P-3 Production Improvement

Actinosynnema pretiosum ATCC 31280 is the producer of antitumor agent ansamitocin P-3 (AP-3). Understanding of the AP-3 biosynthetic pathway and the whole metabolic network in A. pretiosum is important for the improvement of AP-3 titer. In this study, we reconstructed the first complete Genome-Scale...

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Detalles Bibliográficos
Autores principales: Li, Jian, Sun, Renliang, Ning, Xinjuan, Wang, Xinran, Wang, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070911/
https://www.ncbi.nlm.nih.gov/pubmed/30036981
http://dx.doi.org/10.3390/genes9070364