ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer

BACKGROUND: In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway me...

Descripción completa

Detalles Bibliográficos
Autores principales: Roseweir, Antonia K., Halcrow, Elaine S., Chichilo, Sergey, Powell, Arfon GMT, McMillan, Donald C., Horgan, Paul G., Edwards, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070918/
https://www.ncbi.nlm.nih.gov/pubmed/29988110
http://dx.doi.org/10.1038/s41416-018-0174-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070918/
https://www.ncbi.nlm.nih.gov/pubmed/29988110
http://dx.doi.org/10.1038/s41416-018-0174-y

Ejemplares similares