Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways

It is hypothesized that the uremic toxin indoxyl sulfate (IS) plays a role in the pathogenesis of renal anemia. To further explore that hypothesis, we examined the effects of IS on reactive oxygen species (ROS) production, levels of reduced glutathione (GSH), and erythrocyte death (eryptosis) in red...

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Detalles Bibliográficos
Autores principales: Dias, Gabriela Ferreira, Bonan, Natalia Borges, Steiner, Thiago Maass, Tozoni, Sara Soares, Rodrigues, Silvia, Nakao, Lia Sumie, Kuntsevich, Viktoriya, Pecoits Filho, Roberto, Kotanko, Peter, Moreno-Amaral, Andréa N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071035/
https://www.ncbi.nlm.nih.gov/pubmed/29976888
http://dx.doi.org/10.3390/toxins10070280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071035/
https://www.ncbi.nlm.nih.gov/pubmed/29976888
http://dx.doi.org/10.3390/toxins10070280

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