Evolutionary Divergent Suppressor Mutations in Conformational Diseases

Neutral and adaptive mutations are key players in the evolutionary dynamics of proteins at molecular, cellular and organismal levels. Conversely, largely destabilizing mutations are rarely tolerated by evolution, although their occurrence in diverse human populations has important roles in the patho...

Descripción completa

Detalles Bibliográficos
Autores principales: Mesa-Torres, Noel, Betancor-Fernández, Isabel, Oppici, Elisa, Cellini, Barbara, Salido, Eduardo, Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071075/
https://www.ncbi.nlm.nih.gov/pubmed/30011855
http://dx.doi.org/10.3390/genes9070352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071075/
https://www.ncbi.nlm.nih.gov/pubmed/30011855
http://dx.doi.org/10.3390/genes9070352

Ejemplares similares