(−)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study

Upon acylation of the proteasome by the β-lactone inhibitor salinosporamide A (SalA), tetrahydrofuran formation occurs by intramolecular alkylation of the incipient alkoxide onto the choroethyl sidechain and irreversibly blocks the active site. Our previously described synthetic approach to SalA, ut...

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Detalles Bibliográficos
Autores principales: Groll, Michael, Nguyen, Henry, Vellalath, Sreekumar, Romo, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071143/
https://www.ncbi.nlm.nih.gov/pubmed/30029468
http://dx.doi.org/10.3390/md16070240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071143/
https://www.ncbi.nlm.nih.gov/pubmed/30029468
http://dx.doi.org/10.3390/md16070240

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