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(−)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study

Upon acylation of the proteasome by the β-lactone inhibitor salinosporamide A (SalA), tetrahydrofuran formation occurs by intramolecular alkylation of the incipient alkoxide onto the choroethyl sidechain and irreversibly blocks the active site. Our previously described synthetic approach to SalA, ut...

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Detalles Bibliográficos
Autores principales:	Groll, Michael, Nguyen, Henry, Vellalath, Sreekumar, Romo, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071143/ https://www.ncbi.nlm.nih.gov/pubmed/30029468 http://dx.doi.org/10.3390/md16070240

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