Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms

Hepatitis C virus (HCV) causes a major health burden and can be effectively treated by direct-acting antivirals (DAAs). The non-structural protein 5A (NS5A), which plays a role in the viral genome replication, is one of the DAAs’ targets. Resistance-associated viruses (RAVs) harbouring NS5A resistan...

Descripción completa

Detalles Bibliográficos
Autores principales: Knops, Elena, Sierra, Saleta, Kalaghatgi, Prabhav, Heger, Eva, Kaiser, Rolf, Kalinina, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071292/
https://www.ncbi.nlm.nih.gov/pubmed/29986475
http://dx.doi.org/10.3390/genes9070343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071292/
https://www.ncbi.nlm.nih.gov/pubmed/29986475
http://dx.doi.org/10.3390/genes9070343

Ejemplares similares