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Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms

Hepatitis C virus (HCV) causes a major health burden and can be effectively treated by direct-acting antivirals (DAAs). The non-structural protein 5A (NS5A), which plays a role in the viral genome replication, is one of the DAAs’ targets. Resistance-associated viruses (RAVs) harbouring NS5A resistan...

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Detalles Bibliográficos
Autores principales:	Knops, Elena, Sierra, Saleta, Kalaghatgi, Prabhav, Heger, Eva, Kaiser, Rolf, Kalinina, Olga V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071292/ https://www.ncbi.nlm.nih.gov/pubmed/29986475 http://dx.doi.org/10.3390/genes9070343

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