Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma

Rationale: Tumor-associated fibroblasts (TAFs) play a critical role in the suppressive immune tumor microenvironment (TME), compromising the efficacy of immunotherapy. To overcome this therapeutic hurdle, we developed a nanoemulsion (NE) formulation to deliver fraxinellone (Frax), an anti-fibrotic m...

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Detalles Bibliográficos
Autores principales: Hou, Lin, Liu, Qi, Shen, Limei, Liu, Yun, Zhang, Xueqiong, Chen, Fengqian, Huang, Leaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071534/
https://www.ncbi.nlm.nih.gov/pubmed/30083259
http://dx.doi.org/10.7150/thno.24821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071534/
https://www.ncbi.nlm.nih.gov/pubmed/30083259
http://dx.doi.org/10.7150/thno.24821

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