MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)+ multiple myeloma (MM) patients, believed to be the driving factor in the pathogenesis of this MM subtype. MMSET overexpression in MM leads to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in hist...

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Detalles Bibliográficos
Autores principales: Shah, Mrinal Y., Martinez-Garcia, Eva, Phillip, Jude M., Chambliss, Allison B., Popovic, Relja, Ezponda, Teresa, Small, Eliza C., Will, Christine, Phillip, Madonna P., Neri, Paola, Bahlis, Nizar J., Wirtz, Denis, Licht, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071667/
https://www.ncbi.nlm.nih.gov/pubmed/27109101
http://dx.doi.org/10.1038/onc.2016.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071667/
https://www.ncbi.nlm.nih.gov/pubmed/27109101
http://dx.doi.org/10.1038/onc.2016.116

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