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Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH

Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial for adhesion, colonization and infection. Follo...

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Detalles Bibliográficos
Autores principales: Beiroth, Femke, Koudelka, Tomas, Overath, Thorsten, Knight, Stefan D, Tholey, Andreas, Lindhorst, Thisbe K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071696/
https://www.ncbi.nlm.nih.gov/pubmed/30112094
http://dx.doi.org/10.3762/bjoc.14.163