Effects of Neonicotinoid Pesticides on Promoter-Specific Aromatase (CYP19) Expression in Hs578t Breast Cancer Cells and the Role of the VEGF Pathway

BACKGROUND: Aromatase (CYP19) is a key enzyme in estrogens biosynthesis. In the mammary gland, CYP19 gene is expressed at low levels under the regulation of its I.4 promoter. In hormone-dependent breast cancer, fibroblast cells surrounding the tumor express increased levels of CYP19 mRNA due to a de...

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Detalles Bibliográficos
Autores principales: Caron-Beaudoin, Élyse, Viau, Rachel, Sanderson, J. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071809/
https://www.ncbi.nlm.nih.gov/pubmed/29701941
http://dx.doi.org/10.1289/EHP2698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071809/
https://www.ncbi.nlm.nih.gov/pubmed/29701941
http://dx.doi.org/10.1289/EHP2698

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