Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors

The enzymes isocitrate lyase (ICL) isoforms 1 and 2 are essential for Mycobacterium tuberculosis survival within macrophages during latent tuberculosis (TB). As such, ICLs are attractive therapeutic targets for the treatment of tuberculosis. However, there are few biophysical assays that are availab...

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Detalles Bibliográficos
Autores principales: Bhusal, Ram Prasad, Patel, Krunal, Kwai, Brooke X. C., Swartjes, Anne, Bashiri, Ghader, Reynisson, Jóhannes, Sperry, Jonathan, Leung, Ivanhoe K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072051/
https://www.ncbi.nlm.nih.gov/pubmed/30108733
http://dx.doi.org/10.1039/c7md00456g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072051/
https://www.ncbi.nlm.nih.gov/pubmed/30108733
http://dx.doi.org/10.1039/c7md00456g

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