Cargando…

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors

The enzymes isocitrate lyase (ICL) isoforms 1 and 2 are essential for Mycobacterium tuberculosis survival within macrophages during latent tuberculosis (TB). As such, ICLs are attractive therapeutic targets for the treatment of tuberculosis. However, there are few biophysical assays that are availab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhusal, Ram Prasad, Patel, Krunal, Kwai, Brooke X. C., Swartjes, Anne, Bashiri, Ghader, Reynisson, Jóhannes, Sperry, Jonathan, Leung, Ivanhoe K. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072051/ https://www.ncbi.nlm.nih.gov/pubmed/30108733 http://dx.doi.org/10.1039/c7md00456g

Ejemplares similares

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
por: Bhusal, Ram Prasad, et al.
Publicado: (2019)

Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase
por: Ibeji, Collins U., et al.
Publicado: (2020)

Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis
por: Bi, Jing, et al.
Publicado: (2017)

Discovery of a Novel Inhibitor Structure of Mycobacterium tuberculosis Isocitrate Lyase
por: Duan, Changyuan, et al.
Publicado: (2022)

Potential Inhibitors for Isocitrate Lyase of Mycobacterium tuberculosis and Non-M. tuberculosis: A Summary
por: Lee, Yie-Vern, et al.
Publicado: (2015)

Identification of Concomitant Inhibitors against Glutamine Synthetase and Isocitrate Lyase in Mycobacterium tuberculosis from Natural Sources
por: Chanda, Anesha, et al.
Publicado: (2022)

Isocitrate lyase plays important roles in plant salt tolerance
por: Yuenyong, Worawat, et al.
Publicado: (2019)

Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility
por: Shukla, Harish, et al.
Publicado: (2017)

Interaction of Isocitrate Lyase with Proteins Involved in the Energetic Metabolism in Paracoccidioides lutzii
por: Freitas e Silva, Kleber Santiago, et al.
Publicado: (2020)

Characterization of a Functional Role of the Bradyrhizobium japonicum Isocitrate Lyase in Desiccation Tolerance
por: Jeon, Jeong-Min, et al.
Publicado: (2015)

The Role of Isocitrate Lyase (ICL1) in the Metabolic Adaptation of Candida albicans Biofilms
por: Ishola, Oluwaseun Ayodeji, et al.
Publicado: (2016)

Evaluation of Mycobacterium avium subsp. paratuberculosis isocitrate lyase (IcL) and ABC transporter (BacA) knockout mutants as vaccine candidates
por: Eshraghisamani, Razieh, et al.
Publicado: (2023)

Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens
por: Alhasawi, Azhar A., et al.
Publicado: (2019)

Inhibitory Effects of Epipolythiodioxopiperazine Fungal Metabolites on Isocitrate Lyase in the Glyoxylate Cycle of Candida albicans
por: Hwang, Ji-Yeon, et al.
Publicado: (2021)

Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans
por: Kim, Heegyu, et al.
Publicado: (2019)

Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle
por: Lee, So-Hyoung, et al.
Publicado: (2014)

In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa
por: Kwofie, Samuel K., et al.
Publicado: (2018)

Physiological role of isocitrate lyase in dibenzo-p-dioxin and dibenzofuran metabolism by Sphingomonas wittichii RW1
por: Faisal, Rayan M., et al.
Publicado: (2022)

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target
por: Eurtivong, Chatchakorn, et al.
Publicado: (2023)

Type III secretion system expression in oxygen-limited Pseudomonas aeruginosa cultures is stimulated by isocitrate lyase activity
por: Chung, Jade C. S., et al.
Publicado: (2013)

Inhibition of Paracoccidioides lutzii Pb01 Isocitrate Lyase by the Natural Compound Argentilactone and Its Semi-Synthetic Derivatives
por: do Prado, Renata Silva, et al.
Publicado: (2014)

Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism
por: Kwon, Sunghark, et al.
Publicado: (2021)

Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans
por: Chung, Beomkoo, et al.
Publicado: (2022)

Hypothetical protein FoDbp40 influences the growth and virulence of Fusarium oxysporum by regulating the expression of isocitrate lyase
por: Zhao, Busi, et al.
Publicado: (2022)

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)
por: Mak, Oi Wei, et al.
Publicado: (2019)

Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis
por: Jung, James, et al.
Publicado: (2016)

Optimization of protein samples for NMR using thermal shift assays
por: Kozak, Sandra, et al.
Publicado: (2016)

A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
por: Boulton, Stephen, et al.
Publicado: (2014)

Metabolic Engineering of Cofactor F(420) Production in Mycobacterium smegmatis
por: Bashiri, Ghader, et al.
Publicado: (2010)

Lipid transport across the mycobacterial cell envelope
por: Bashiri, Ghader
Publicado: (2021)

(13)C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation
por: Beste, Dany J. V., et al.
Publicado: (2011)

Tat–Dependent Translocation of an F(420)–Binding Protein of Mycobacterium tuberculosis
por: Bashiri, Ghader, et al.
Publicado: (2012)

Identification of Mannich Base as a Novel Inhibitor of Mycobacterium Tuberculosis Isocitrate by High-Throughput Screening
por: Ji, Lei, et al.
Publicado: (2011)

RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity
por: Abdou, Elias, et al.
Publicado: (2017)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
por: Su, Li, et al.
Publicado: (2020)

NightShift: NMR shift inference by general hybrid model training - a framework for NMR chemical shift prediction
por: Dehof, Anna Katharina, et al.
Publicado: (2013)

Isocitrate dehydrogenase mutations in myeloid malignancies
por: Medeiros, B C, et al.
Publicado: (2017)

Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation
por: Banerjee, Sharmistha, et al.
Publicado: (2005)

Structural and functional insights into the reaction specificity of catalase-related hydroperoxide lyase: A shift from lyase activity to allene oxide synthase by site-directed mutagenesis
por: Teder, Tarvi, et al.
Publicado: (2017)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
por: Liu, Xiaoyan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ja3etjfgkn5br2l905ctsb298e