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A marginalized two-part Beta regression model for microbiome compositional data

In microbiome studies, an important goal is to detect differential abundance of microbes across clinical conditions and treatment options. However, the microbiome compositional data (quantified by relative abundance) are highly skewed, bounded in [0, 1), and often have many zeros. A two-part model i...

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Detalles Bibliográficos
Autores principales: Chai, Haitao, Jiang, Hongmei, Lin, Lu, Liu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072097/
https://www.ncbi.nlm.nih.gov/pubmed/30036363
http://dx.doi.org/10.1371/journal.pcbi.1006329