Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3

[Image: see text] Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity f...

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Detalles Bibliográficos
Autores principales: Ansideri, Francesco, Macedo, Joana T., Eitel, Michael, El-Gokha, Ahmed, Zinad, Dhafer S., Scarpellini, Camilla, Kudolo, Mark, Schollmeyer, Dieter, Boeckler, Frank M., Blaum, Bärbel S., Laufer, Stefan A., Koch, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072243/
https://www.ncbi.nlm.nih.gov/pubmed/30087925
http://dx.doi.org/10.1021/acsomega.8b00668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072243/
https://www.ncbi.nlm.nih.gov/pubmed/30087925
http://dx.doi.org/10.1021/acsomega.8b00668

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