N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer

Natural prenylated indoles have been proposed as potential anticancer agents. To exploit this discovery for developing new peptide therapeutics, we report the first studies whereby incorporation of prenylated indoles into primary sequences has been achieved. We developed a route to synthesise N(α)-F...

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Detalles Bibliográficos
Autores principales: Offerman, Shaun C., Kadirvel, Manikandan, Abusara, Osama H., Bryant, Jennifer L., Telfer, Brian A., Brown, Gavin, Freeman, Sally, White, Anne, Williams, Kaye J., Aojula, Harmesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072501/
https://www.ncbi.nlm.nih.gov/pubmed/30108771
http://dx.doi.org/10.1039/c6md00691d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072501/
https://www.ncbi.nlm.nih.gov/pubmed/30108771
http://dx.doi.org/10.1039/c6md00691d

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