Genome doubling shapes the evolution and prognosis of advanced cancers

Ploidy abnormalities are a hallmark of human cancers, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied by tumor lineage and molecular...

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Detalles Bibliográficos
Autores principales: Bielski, Craig M., Zehir, Ahmet, Penson, Alexander V., Donoghue, Mark T.A., Chatila, Walid, Armenia, Joshua, Chang, Matthew T., Schram, Alison M., Jonsson, Philip, Bandlamudi, Chaitanya, Razavi, Pedram, Iyer, Gopa, Robson, Mark E., Stadler, Zsofia K., Schultz, Nikolaus, Baselga, Jose, Solit, David B., Hyman, David M., Berger, Michael F., Taylor, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072608/
https://www.ncbi.nlm.nih.gov/pubmed/30013179
http://dx.doi.org/10.1038/s41588-018-0165-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072608/
https://www.ncbi.nlm.nih.gov/pubmed/30013179
http://dx.doi.org/10.1038/s41588-018-0165-1

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