Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer

Monoclonal antibodies (mAbs) are used as targeted therapies against cancers. These mAbs kill cancer cells via various mechanisms of actions. In this study, human embryonic stem cells (hESCs) was used as the immunogen to generate a panel of antibodies. From this panel of mAbs, A19 was found to bind b...

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Detalles Bibliográficos
Autores principales: Tan, Heng Liang, Yong, Charlene, Tan, Bao Zhu, Fong, Wey Jia, Padmanabhan, Jayanthi, Chin, Angela, Ding, Vanessa, Lau, Ally, Zheng, Lu, Bi, Xuezhi, Yang, Yuansheng, Choo, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072701/
https://www.ncbi.nlm.nih.gov/pubmed/30072783
http://dx.doi.org/10.1038/s41598-018-30070-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072701/
https://www.ncbi.nlm.nih.gov/pubmed/30072783
http://dx.doi.org/10.1038/s41598-018-30070-z

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