Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3

All lung cancers patients with epidermal growth factor receptor (EGFR) mutation inevitably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). In up to 30% of cases, the mechanism underlying acquired resistance remains unknown. MicroRNAs (miRNAs) is a group of small non-coding RNAs...

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Detalles Bibliográficos
Autores principales: Yue, Jinnan, Lv, Dacheng, Wang, Caiyun, Li, Ling, Zhao, Qingnan, Chen, Hongzhuan, Xu, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072709/
https://www.ncbi.nlm.nih.gov/pubmed/29717264
http://dx.doi.org/10.1038/s41388-018-0276-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072709/
https://www.ncbi.nlm.nih.gov/pubmed/29717264
http://dx.doi.org/10.1038/s41388-018-0276-2

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