Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells

Fragile X syndrome (FXS) is caused by transcriptional silencing of the FMR1 gene during embryonic development with the consequent loss of the encoded fragile X mental retardation protein (FMRP). The pathological mechanisms of FXS have been extensively studied using the Fmr1-knockout mouse, and the f...

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Detalles Bibliográficos
Autores principales: Sunamura, Naohiro, Iwashita, Shinzo, Enomoto, Kei, Kadoshima, Taisuke, Isono, Fujio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072755/
https://www.ncbi.nlm.nih.gov/pubmed/30072797
http://dx.doi.org/10.1038/s41598-018-30025-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072755/
https://www.ncbi.nlm.nih.gov/pubmed/30072797
http://dx.doi.org/10.1038/s41598-018-30025-4

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