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Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells

Fragile X syndrome (FXS) is caused by transcriptional silencing of the FMR1 gene during embryonic development with the consequent loss of the encoded fragile X mental retardation protein (FMRP). The pathological mechanisms of FXS have been extensively studied using the Fmr1-knockout mouse, and the f...

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Detalles Bibliográficos
Autores principales:	Sunamura, Naohiro, Iwashita, Shinzo, Enomoto, Kei, Kadoshima, Taisuke, Isono, Fujio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072755/ https://www.ncbi.nlm.nih.gov/pubmed/30072797 http://dx.doi.org/10.1038/s41598-018-30025-4

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