Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

Amino acid transporters alanine-serine-cysteine transporter 2 (ASCT2) and L-Type Amino Acid Transporter 1 (LAT1) are coordinately enhanced in human cancers where among other roles, they are thought to drive mechanistic target-of-rapamycin (mTOR) growth signaling. To assess ASCT2 and LAT1 as therapeu...

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Detalles Bibliográficos
Autores principales: Bothwell, Paige J., Kron, Clare D., Wittke, Evan F., Czerniak, Bradley N., Bode, Barrie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073291/
https://www.ncbi.nlm.nih.gov/pubmed/30029480
http://dx.doi.org/10.3390/ijms19072093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073291/
https://www.ncbi.nlm.nih.gov/pubmed/30029480
http://dx.doi.org/10.3390/ijms19072093

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