Quantum Mechanics/Molecular Mechanics Studies on the Relative Reactivities of Compound I and II in Cytochrome P450 Enzymes

The cytochromes P450 are drug metabolizing enzymes in the body that typically react with substrates through a monoxygenation reaction. During the catalytic cycle two reduction and protonation steps generate a high-valent iron (IV)-oxo heme cation radical species called Compound I. However, with suff...

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Detalles Bibliográficos
Autores principales: Postils, Verònica, Saint-André, Maud, Timmins, Amy, Li, Xiao-Xi, Wang, Yong, Luis, Josep M., Solà, Miquel, de Visser, Sam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073316/
https://www.ncbi.nlm.nih.gov/pubmed/29986417
http://dx.doi.org/10.3390/ijms19071974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073316/
https://www.ncbi.nlm.nih.gov/pubmed/29986417
http://dx.doi.org/10.3390/ijms19071974

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