Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

Platinum(II) drugs are activated intracellularly by aquation of the leaving groups and then bind to DNA, forming DNA adducts capable to activate various signal-transduction pathways. Mostly explored in recent years are Pt(IV) complexes which allow the presence of two additional ligands in the axial...

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Detalles Bibliográficos
Autores principales: Savino, Salvatore, Marzano, Cristina, Gandin, Valentina, Hoeschele, James D., Natile, Giovanni, Margiotta, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073472/
https://www.ncbi.nlm.nih.gov/pubmed/30011897
http://dx.doi.org/10.3390/ijms19072050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073472/
https://www.ncbi.nlm.nih.gov/pubmed/30011897
http://dx.doi.org/10.3390/ijms19072050

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