Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs

Telomeres, the natural ends of chromosomes, hide the linear telomeric DNA from constitutive exposure to the DNA damage response with a lariat structure or t-loop. Progressive telomere shortening associated with DNA replication in the absence of a compensatory mechanism culminates in t-loop collapse...

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Detalles Bibliográficos
Autores principales: Bernal, Aina, Zafon, Elisenda, Domínguez, Daniel, Bertran, Enric, Tusell, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073565/
https://www.ncbi.nlm.nih.gov/pubmed/30018248
http://dx.doi.org/10.3390/ijms19072078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073565/
https://www.ncbi.nlm.nih.gov/pubmed/30018248
http://dx.doi.org/10.3390/ijms19072078

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