Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton

Background: Nuclear receptors (NRs) are considered as potential drug targets because they control diverse biological functions. However, steroidal ligands for NRs have the potential to cross-react with other nuclear receptors, so development of non-steroidal NR ligands is desirable to obtain safer a...

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Detalles Bibliográficos
Autores principales: Nishiyama, Yuko, Fujii, Shinya, Makishima, Makoto, Hashimoto, Yuichi, Ishikawa, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073568/
https://www.ncbi.nlm.nih.gov/pubmed/30021999
http://dx.doi.org/10.3390/ijms19072090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073568/
https://www.ncbi.nlm.nih.gov/pubmed/30021999
http://dx.doi.org/10.3390/ijms19072090

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