Cargando…

Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

Purine homeostasis is maintained by a purine cycle in which the regulated member is a cytosolic 5′-nucleotidase II (cN-II) hydrolyzing IMP and GMP. Its expression is particularly high in proliferating cells, indeed high cN-II activity or expression in hematological malignancy has been associated to...

Descripción completa

Detalles Bibliográficos
Autores principales: Pesi, Rossana, Petrotto, Edoardo, Colombaioni, Laura, Allegrini, Simone, Garcia-Gil, Mercedes, Camici, Marcella, Jordheim, Lars Petter, Tozzi, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073589/
https://www.ncbi.nlm.nih.gov/pubmed/30037008
http://dx.doi.org/10.3390/ijms19072115