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Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

Purine homeostasis is maintained by a purine cycle in which the regulated member is a cytosolic 5′-nucleotidase II (cN-II) hydrolyzing IMP and GMP. Its expression is particularly high in proliferating cells, indeed high cN-II activity or expression in hematological malignancy has been associated to...

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Detalles Bibliográficos
Autores principales:	Pesi, Rossana, Petrotto, Edoardo, Colombaioni, Laura, Allegrini, Simone, Garcia-Gil, Mercedes, Camici, Marcella, Jordheim, Lars Petter, Tozzi, Maria Grazia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073589/ https://www.ncbi.nlm.nih.gov/pubmed/30037008 http://dx.doi.org/10.3390/ijms19072115

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