Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation

The role of epigenetic alterations in the pathogenesis of retinal degenerative diseases, including age-related macular degeneration (AMD), has been pending so far. Our study investigated the effect of oxidative stress and inflammation on DNA methyltransferases (DNMTs) and Sirtuin 1 (SIRT1) functions...

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Detalles Bibliográficos
Autores principales: Maugeri, Andrea, Barchitta, Martina, Mazzone, Maria Grazia, Giuliano, Francesco, Basile, Guido, Agodi, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073744/
https://www.ncbi.nlm.nih.gov/pubmed/30037017
http://dx.doi.org/10.3390/ijms19072118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073744/
https://www.ncbi.nlm.nih.gov/pubmed/30037017
http://dx.doi.org/10.3390/ijms19072118

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