Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

The small molecules, natural antioxidant Caffeic Acid (trans-3,4-Dihydroxycinnamic acid CA) and anti-diabetic drug Metformin (Met), activate 5′-adenosine monophosphate-activated protein kinase (AMPK) and interfere with metabolic reprogramming in human cervical squamous carcinoma cells. Here, to gain...

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Detalles Bibliográficos
Autores principales: Tyszka-Czochara, Malgorzata, Bukowska-Strakova, Karolina, Kocemba-Pilarczyk, Kinga A., Majka, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073805/
https://www.ncbi.nlm.nih.gov/pubmed/29958416
http://dx.doi.org/10.3390/nu10070841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073805/
https://www.ncbi.nlm.nih.gov/pubmed/29958416
http://dx.doi.org/10.3390/nu10070841

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