Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2

The influence of Arginine 117 of human cytochrome P450 2J2 in the recognition of ebastine and a series of terfenadone derivatives was studied by site-directed mutagenesis. R117K, R117E, and R117L mutants were produced, and the behavior of these mutants in the hydroxylation of ebastine and terfenadon...

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Detalles Bibliográficos
Autores principales: Lafite, Pierre, André, François, Graves, Joan P., Zeldin, Darryl C., Dansette, Patrick M., Mansuy, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073854/
https://www.ncbi.nlm.nih.gov/pubmed/30012976
http://dx.doi.org/10.3390/ijms19072066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073854/
https://www.ncbi.nlm.nih.gov/pubmed/30012976
http://dx.doi.org/10.3390/ijms19072066

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