Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies

Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the function of these sites has not been directly demonstrated. Here, by combining nasc...

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Detalles Bibliográficos
Autores principales: Boulay, Gaylor, Volorio, Angela, Iyer, Sowmya, Broye, Liliane C., Stamenkovic, Ivan, Riggi, Nicolo, Rivera, Miguel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075149/
https://www.ncbi.nlm.nih.gov/pubmed/30042132
http://dx.doi.org/10.1101/gad.315192.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075149/
https://www.ncbi.nlm.nih.gov/pubmed/30042132
http://dx.doi.org/10.1101/gad.315192.118

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