Deregulation of the G1/S-phase transition is the proximal cause of mortality in old yeast mother cells

Budding yeast cells produce a finite number of daughter cells before they die. Why old yeast cells stop dividing and die is unclear. We found that age-induced accumulation of the G1/S-phase inhibitor Whi5 and defects in G1/S cyclin transcription cause cell cycle delays and genomic instability that r...

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Detalles Bibliográficos
Autores principales: Neurohr, Gabriel E., Terry, Rachel L., Sandikci, Arzu, Zou, Ke, Li, Hao, Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075151/
https://www.ncbi.nlm.nih.gov/pubmed/30042134
http://dx.doi.org/10.1101/gad.312140.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075151/
https://www.ncbi.nlm.nih.gov/pubmed/30042134
http://dx.doi.org/10.1101/gad.312140.118

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