The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases

Inhibitors targeting bacterial enzymes should not interfere with enzymes of the host, and knowledge about structural determinants for selectivity is important for designing inhibitors with a therapeutic potential. We have determined the binding strengths of two hydroxamate compounds, galardin and co...

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Detalles Bibliográficos
Autores principales: Sylte, Ingebrigt, Dawadi, Rangita, Malla, Nabin, von Hofsten, Susannah, Nguyen, Tra-Mi, Solli, Ann Iren, Berg, Eli, Adekoya, Olayiwola A., Svineng, Gunbjørg, Winberg, Jan-Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075749/
https://www.ncbi.nlm.nih.gov/pubmed/30075004
http://dx.doi.org/10.1371/journal.pone.0200237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075749/
https://www.ncbi.nlm.nih.gov/pubmed/30075004
http://dx.doi.org/10.1371/journal.pone.0200237

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