Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome

BACKGROUND: Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS exhibit ubiquitous progerin expression, accelerated aging and atherosclerosis, and die in their early teens, mainly of myocardial i...

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Detalles Bibliográficos
Autores principales: Hamczyk, Magda R., Villa-Bellosta, Ricardo, Gonzalo, Pilar, Andrés-Manzano, María J., Nogales, Paula, Bentzon, Jacob F., López-Otín, Carlos, Andrés, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075893/
https://www.ncbi.nlm.nih.gov/pubmed/29490993
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075893/
https://www.ncbi.nlm.nih.gov/pubmed/29490993
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030856

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