Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression

Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs synergize with the attenuated oncolytic vesicular stoma...

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Detalles Bibliográficos
Autores principales: Beug, Shawn T., Pichette, Stephanie J., St-Jean, Martine, Holbrook, Janelle, Walker, Danielle E., LaCasse, Eric C., Korneluk, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076221/
https://www.ncbi.nlm.nih.gov/pubmed/30101187
http://dx.doi.org/10.1016/j.omto.2018.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076221/
https://www.ncbi.nlm.nih.gov/pubmed/30101187
http://dx.doi.org/10.1016/j.omto.2018.06.002

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