Photoacoustic imaging reconstruction using combined nonlocal patch and total-variation regularization for straight-line scanning

BACKGROUND: For practical straight-line scanning in photoacoustic imaging (PAI), serious artifacts caused by missing data will occur. Traditional total variation (TV)-based algorithms fail to obtain satisfactory results, with an over-smoothed and blurred geometric structure. Therefore, it is important to develop a new algorithm to improve the quality of practical straight-line reconstructed images. METHODS: In this paper, a combined nonlocal patch and TV-based regularization model for PAI reconstruction is proposed to solve these problems. A modified adaptive nonlocal weight function is adopted to provide more reliable estimations for the similarities between patches. Similar patches are searched for throughout the entire image; thus, this model realizes adaptive search for the neighborhood of the patch. The optimization problem is simplified to a common iterative PAI reconstruction problem. RESULTS AND CONCLUSION: The proposed algorithm is validated by a series of numerical simulations and an in vitro experiment for straight-line scanning. The results of patch-TV are compared to those of two mainstream TV-based algorithms as well as the iterative algorithm only with patch-based regularization. Moreover, the peak signal-to-noise ratio, the noise robustness, and the convergence and calculation speeds are compared and discussed. The results show that the proposed patch-TV yields significant improvement over the other three algorithms qualitatively and quantitatively. These simulations and experiment indicate that the patch-TV algorithm successfully solves the problems of PAI reconstruction and is highly effective in practical PAI applications.