PIAS-family proteins negatively regulate Glis3 transactivation function through SUMO modification in pancreatic β cells

Gli-similar 3 (Glis3) is Krüppel-like transcription factor associated with the transcriptional regulation of insulin. Mutations within the Glis3 locus have been implicated in a number of pathologies including diabetes mellitus and hypothyroidism. Despite its clinical significance, little is known ab...

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Detalles Bibliográficos
Autores principales: Hoard, Tyler M., Yang, Xiao Ping, Jetten, Anton M., ZeRuth, Gary T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077130/
https://www.ncbi.nlm.nih.gov/pubmed/30094379
http://dx.doi.org/10.1016/j.heliyon.2018.e00709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077130/
https://www.ncbi.nlm.nih.gov/pubmed/30094379
http://dx.doi.org/10.1016/j.heliyon.2018.e00709

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