Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice

Despite its antimicrobial activity, nitrofurantoin (NFT) is a renal carcinogen in rats. Oxidative stress induced by reduction of the nitro group of NFT may contribute to its genotoxicity. This is supported by our recent results indicating that the structure of the nitrofuran plays a key role in NFT-...

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Detalles Bibliográficos
Autores principales: Tsuchiya, Takuma, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Yokoo, Yuh, Nishikawa, Akiyoshi, Yanai, Tokuma, Umemura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077154/
https://www.ncbi.nlm.nih.gov/pubmed/30093786
http://dx.doi.org/10.1293/tox.2018-0014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077154/
https://www.ncbi.nlm.nih.gov/pubmed/30093786
http://dx.doi.org/10.1293/tox.2018-0014

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