Imaging mass spectrometry for toxicity assessment: a useful technique to confirm drug distribution in histologically confirmed lesions

To evaluate the usefulness of imaging mass spectrometry (IMS) technology for assessing drug toxicity, we analyzed animal tissues in an amiodarone (AMD)-induced phospholipidosis model by IMS and confirmed the relationship between the distribution of AMD, its metabolites, and representative phospholip...

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Detalles Bibliográficos
Autores principales: Kashimura, Akane, Tanaka, Kouji, Sato, Hiroko, Kaji, Hidefumi, Tanaka, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2018
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077156/
https://www.ncbi.nlm.nih.gov/pubmed/30093793
http://dx.doi.org/10.1293/tox.2018-0006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077156/
https://www.ncbi.nlm.nih.gov/pubmed/30093793
http://dx.doi.org/10.1293/tox.2018-0006

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