Cargando…
A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during latency. Mutation and inhibitor studies reveal that LUNA en...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077246/ https://www.ncbi.nlm.nih.gov/pubmed/30021158 http://dx.doi.org/10.1016/j.celrep.2018.06.048 |