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A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during latency. Mutation and inhibitor studies reveal that LUNA en...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077246/ https://www.ncbi.nlm.nih.gov/pubmed/30021158 http://dx.doi.org/10.1016/j.celrep.2018.06.048 |