The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses

Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin durin...

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Detalles Bibliográficos
Autores principales: Keppler, Selina Jessica, Burbage, Marianne, Gasparrini, Francesca, Hartjes, Lara, Aggarwal, Shweta, Massaad, Michel J., Geha, Raif S., Bruckbauer, Andreas, Batista, Facundo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077251/
https://www.ncbi.nlm.nih.gov/pubmed/30021160
http://dx.doi.org/10.1016/j.celrep.2018.06.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077251/
https://www.ncbi.nlm.nih.gov/pubmed/30021160
http://dx.doi.org/10.1016/j.celrep.2018.06.051

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