Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites

Upon activation, the epidermal growth factor receptor (EGFR) phosphorylates tyrosine residues in its cytoplasmic tail, which triggers the binding of Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains and initiates downstream signaling. The sequences flanking the tyrosine residues (referr...

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Detalles Bibliográficos
Autores principales: Cantor, Aaron J., Shah, Neel H., Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077704/
https://www.ncbi.nlm.nih.gov/pubmed/30012625
http://dx.doi.org/10.1073/pnas.1803598115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077704/
https://www.ncbi.nlm.nih.gov/pubmed/30012625
http://dx.doi.org/10.1073/pnas.1803598115

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