A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma

BACKGROUND: Purinergic receptors control cell proliferation, apoptosis, migration, inflammation, and cytokine secretion. Increased expression of specific purinergic receptors is reported in asthma. The role of purinergic P2Y6 receptors (P2Y6R) in asthma is controversial. HYPOTHESIS: P2Y6R activation...

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Detalles Bibliográficos
Autores principales: Chetty, Anne, Sharda, Azeem, Warburton, Rod, Weinberg, Ellen O, Dong, Jinghui, Fang, Min, Sahagian, G Gary, Chen, Tiangmeng, Xue, Chang, Castellot, John J, Haydon, Philip G, Nielsen, Heber C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078081/
https://www.ncbi.nlm.nih.gov/pubmed/30122959
http://dx.doi.org/10.2147/JAA.S151849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078081/
https://www.ncbi.nlm.nih.gov/pubmed/30122959
http://dx.doi.org/10.2147/JAA.S151849

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