Structures of transcription pre-initiation complex with TFIIH and Mediator

For transcription initiation, RNA polymerase (Pol) II assembles with general transcription factors on promoter DNA to form the pre-initiation complex (PIC). We report cryo-EM structures of the yeast PIC and PIC-core Mediator (cMed) complex at nominal resolutions of 4.7 Å and 5.8 Å, respectively. The...

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Detalles Bibliográficos
Autores principales: Schilbach, S., Hantsche, M., Tegunov, D., Dienemann, C., Wigge, C., Urlaub, H., Cramer, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078178/
https://www.ncbi.nlm.nih.gov/pubmed/29088706
http://dx.doi.org/10.1038/nature24282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078178/
https://www.ncbi.nlm.nih.gov/pubmed/29088706
http://dx.doi.org/10.1038/nature24282

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