PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain

The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch receptor intracellular domain (ICD). Using the Caenorhabd...

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Detalles Bibliográficos
Autores principales: Gutnik, Silvia, Thomas, Yann, Guo, Yanwu, Stoecklin, Janosch, Neagu, Anca, Pintard, Lionel, Merlet, Jorge, Ciosk, Rafal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078339/
https://www.ncbi.nlm.nih.gov/pubmed/30012553
http://dx.doi.org/10.1242/bio.034066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078339/
https://www.ncbi.nlm.nih.gov/pubmed/30012553
http://dx.doi.org/10.1242/bio.034066

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